Mechanical stretch upregulates proteins involved in Ca2+sensitization in urinary bladder smooth muscle hypertrophy
نویسندگان
چکیده
منابع مشابه
Mechanical stretch upregulates proteins involved in Ca sensitization in urinary bladder smooth muscle hypertrophy
Ettickan Boopathi, Cristiano Gomes, Stephen A. Zderic, Bruce Malkowicz, Ranjita Chakrabarti, Darshan P. Patel, Alan J. Wein, and Samuel Chacko Division of Urology, Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Hospital das Clinica...
متن کاملMechanical stretch upregulates proteins involved in Ca2+ sensitization in urinary bladder smooth muscle hypertrophy.
Partial bladder outlet obstruction (pBOO)-induced remodeling of bladder detrusor smooth muscle (DSM) is associated with the modulation of cell signals regulating contraction. We analyzed the DSM from obstructed murine urinary bladders for the temporal regulation of RhoA GTPase and Rho-activated kinase (ROCK), which are linked to Ca(2+) sensitization. In addition, the effects of equibiaxial cell...
متن کاملMechanical stretch regulates cell survival in human bladder smooth muscle cells in vitro.
Our understanding of the pathophysiology of the overactive bladder is poor. It has been proposed that localized contractions result in the abnormal stretching of bladder smooth muscle. We hypothesize that stretch regulates the cellular processes that determine tissue size. The purpose of this study was to investigate the effect of stretch on apoptosis, proliferation, cell hypertrophy, and growt...
متن کاملMechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells.
Application of mechanical stimuli has been shown to alter gene expression in bladder smooth muscle cells (SMC). To date, only a limited number of "stretch-responsive" genes in this cell type have been reported. We employed oligonucleotide arrays to identify stretch-sensitive genes in primary culture human bladder SMC subjected to repetitive mechanical stimulation for 4 h. Differential gene expr...
متن کاملObstruction stimulates COX-2 expression in bladder smooth muscle cells via increased mechanical stretch.
Studies were performed to investigate the regulatory mechanism of bladder cyclooxygenase-2 (COX-2) expression after outlet obstruction. In situ hybridization of murine bladder tissues using COX-2-specific riboprobes demonstrated that COX-2 expression was induced predominantly in the bladder smooth muscle cells after outlet obstruction. To study the effect of increased mechanical stretch on COX ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2014
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00033.2014